Nos projets de recherche

Disponible en anglais seulement

Mise à jour septembre 2023

Title Principal Investigator / Supervisor Program Project Start Date Project End Date Total $ Awarded
Studies on the development of biocompatible antimicrobial platelet storage devices Principal Investigator: BROOKS, Don

Co-Investigator(s) / Trainee: HADJESFANDIARI, Narges 		Graduate Fellowship Program 96000.0
Anemia-induced bleeding in thrombocytopenic patients with blood cancer Principal Investigator: ARNOLD, Donald

Co-Investigator(s) / Trainee: MODI, Dimpy 		Graduate Fellowship Program 70000.0
Novel cell-surface engineering methods to increase immune-tolerance of allogenic cell transplantation Principal Investigator: KIZHAKKEDATHU, Jayachandran

Co-Investigator(s) / Trainee: MOON, Haisle 		Graduate Fellowship Program 90333.3
Synthesis and live cell imaging of ice recrystallization inhibitors in red blood cells Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: MCMUNN, Leah 		Graduate Fellowship Program 112333.0
Investigation of pathophysiology, prevention and treatment of murine Transfusion Related Acute Lung Injury (TRALI) Principal Investigator: SEMPLE, John

Co-Investigator(s) / Trainee: McVEY, Mark 		Graduate Fellowship Program 52000.0
Replacing plasma-derived C1 Esterase inhibitor Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: SIVANANTHAN, Sangavi 		Graduate Fellowship Program 70000.0
Studying and alleviating the effects of platelet microparticles induced by pathogen reduction of platelet concentrates Principal Investigator: PROVOST, Patrick

Co-Investigator(s) / Trainee: LAUGIER, Jonathan 		Graduate Fellowship Program 52000.0
Replacement of IVIg by small molecule inhibitors of phagocytosis Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: LORIAMINI, Melika 		Graduate Fellowship Program 112333.0
Impact of storage on the function of cord blood hematopoietic stem and progenitor cells Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: JAHAN, Suria 		Graduate Fellowship Program 104000.0
CD71 Erythroid Cells, RBC Clearance and Sepsis in Donor - Recipient Sex- Mismatched Transfusion Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: LI, Wenhui 		Graduate Fellowship Program 70000.0
Synthesis of carbohydrate derivatives for the improvement of red blood cell storage Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: MEYER, Julia 		Graduate Fellowship Program 79500.0
Transcriptome analyses of Staphylococcus aureus grown in platelet concentrates with focus on virulence Principal Investigator: RAMIREZ-ARCOS, Sandra

Co-Investigator(s) / Trainee: DA SILVA PAREDES, Carina 		Graduate Fellowship Program 122000.0
Fc receptor blockade related to fetal and neonatal alloimmune thrombocytopenia Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: TAWHIDI, Zoya 		Graduate Fellowship Program 70000.0
Cellular therapy to improve CD4+ T-Cell responses in humanized mice infected with HIV-1: adoptive transfer of CD4+ T-cells lacking s-Src activity Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: McCARTHY, Stephen 		Graduate Fellowship Program 96000.0
Investigating the mechanism of anti-CD44 antibody amelioration of IVIg-treatable disease Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: NORRIS, Peter 		Graduate Fellowship Program 112333.3
Assessment of fluorinated ice crystallization inhibitors: cryopreservation of hematopoietic stem cells and red blood cells Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: BRIARD, Jennie 		Graduate Fellowship Program 96000.0
Perioperative transfusion threshold : A population-based observational study Principal Investigator: FERGUSSON, Dean

Co-Investigator(s) / Trainee: VERRET, Michael 		Graduate Fellowship Program 52000.0
Small molecule inhibitors of phagocytosis to replace intravenous immunoglobulin (IVIG) Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: TONG, Tik Nga (Cindy) 		Graduate Fellowship Program 52000.0
Investigating a new class of small molecule ice recrystallization inhibitors for red blood cell cryopreservation Principal Investigator: BEN, Robert

Co-Investigator(s) / Trainee: AMPAW, Anna 		Graduate Fellowship Program 112333.3
Identification of protein biomarkers for red cell quality Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: CHEN, Deborah 		Graduate Fellowship Program 100000.0
Donor factors and product quality Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: YAZDANBAKHSH, Mahsa 		Graduate Fellowship Program 122000.0
Recombinant Fc multimers to replace IVIG Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: LEWIS, Bonnie 		Graduate Fellowship Program 104000.0
Evaluation and improvement of cold stored platelets Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: ZHAO, Hanqi (Wayne) 		Graduate Fellowship Program 112333.3
The in vivo effects of liposome treatment on minimizing membrance injury in rat red blood cells during hypothermic storage Principal Investigator: HOLOVATI, Jelena

Co-Investigator(s) / Trainee: da SILVIERA CAVALCANTE, Luciana 		Graduate Fellowship Program 100000.0
Mechanisms of anti-αIIb mediated miscarriage in fetal and neonatal alloimmune thrombocytopenia Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee: CHEN, Zi Yan 		Graduate Fellowship Program 52000.0
Elucidation of the mechanism of IVIG-associated hemolysis Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: PENDERGRAST, Jacob , CSERTI-GAZDEWICH, Christine , SHEHATA, Nadine , PAVENSKI, Katerina , LAU, Wendy , CALLUM, Jeannie , LIN, Yulia , LIEBERMAN, Lani , HANNACH, Barbara 		Intramural Research Grant Program 393712.0
Anti-RBC monoclonal antibodies as a replacement for IVIg and anti-D in ITP Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: BRANCH, Donald, DUNN, Shannon 		Intramural Research Grant Program 400000.0
Role of blood component manufacturing on microvesicle-induced transfusion-related immune modulation Principal Investigator: ACKER, Jason

Co-Investigator(s) / Trainee: HOLOVATI, Jelena, BRANCH, Donald, ZHANG, Haibo 		Intramural Research Grant Program 250660.0
Can pre-operative anemia be timely identified and optimized in patients awaiting primary arthroplasty surgery? A randomized clinical trial Principal Investigator: GRAMMATOPOULOS, George

Co-Investigator(s) / Trainee: FERGUSSON, Dean, RAMSAY, Tim, TINMOUTH, Alan, GAGNE, Sylvain, MACK, Johnathan, BELZILE, Etienne, BEALE, Paul, THAVORN, Kednapa, TOUCHIE, Donna, GERMAIN, Genevieve, LAROCHE, Vincent 		Intramural Research Grant Program 276081.0
Small molecule drug development of phagocytosis inhibitors Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: KOTRA, Lakshmi, P. 		Intramural Research Grant Program 428468.4
Defining the components of transfusable plasma that reduce bleeding Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: PRYZDIAL, Edward, NI, Heyu 		Intramural Research Grant Program 218230.0
Translating novel clotting factor X function to treat thrombosis Principal Investigator: PRYZDIAL, Ed

Co-Investigator(s) / Trainee: MACVICAR, Brian, SHEFFIELD, William 		Intramural Research Grant Program 369052.0
Human monoclonal CD44 antibodies as potential IVIg replacements Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: NI, Heyu 		Intramural Research Grant Program 336000.0
Anti-GPIb- and anti-GPIIbIIIa- mediated immune thrombocytopenia: Mechanisms and actions of intravenous IgG (IVIG) and alternative therapies Principal Investigator: NI, Heyu

Co-Investigator(s) / Trainee: LAZARUS, Alan, BRANCH, Donald 		Intramural Research Grant Program 412010.3
Revisiting the universal donor: Does exposure to O blood products affect patient outcomes? Principal Investigator: ARNOLD, Donald

Co-Investigator(s) / Trainee: ACKER, Jason, BUCKSTEIN, Rena, CALLUM, Jeannie, COOK, Richard, HEDDLE, Nancy, SOLH, Ziad, WEBERT, Kathryn, BARTY, Rebecca, LEBER, Brian, LALIT, Saini 		Intramural Research Grant Program 378365.0
Plasma versus plasma protein concentrate transfusion for coagulopathic control Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: NI, Heyu 		Intramural Research Grant Program 224417.0
Fc receptors and IVIg in ITP Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: CSERTI-GAZDEWICH, Christine, LIN, Yulia, CALLUM, Jeannie, SHOLZBERG, Michelle, NI, Heyu 		Intramural Research Grant Program 432000.0
Mechanisms of erythrocyte antibody-mediated immune suppression Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: NI, Heyu, SEMPLE, John 		Intramural Research Grant Program 400000.0
A multifaceted intervention to optimize red blood cell transfusion practice in two provinces Principal Investigator: WEBERT, Kathryn

Co-Investigator(s) / Trainee: NAHIRNIAK, Susan, CALLUM, Jeannie, LIN, Yulia, ZELLER, Michelle 		Intramural Research Grant Program 332942.0
IN-TRUST: Using a transfusion database to explore the immune-modulatory impacts of blood transfusion and the clinical impacts of blood processing changes Principal Investigator: NING, Shuoyan

Co-Investigator(s) / Trainee: ARNOLD, Donald, ZELLER, Michelle, ACKER, Jason, LI, Na, HEDDLE, Nancy, HILLIS, Christopher, ROCHWERG, Bram, SYED, Summer 		Intramural Research Grant Program 270352.1
RBC hemolysis and cellular effector mechanisms (RHANCEM) Principal Investigator: BRANCH, Donald

Co-Investigator(s) / Trainee: CSERTI-GAZDEWICH, Christine, PENDERGRAST,Jacob, CALLUM, Jeannie, YI, Qilong 		Intramural Research Grant Program 399927.3
Optimization of monoclonal anti-erythrocyte antibodies for improved immunoprophylaxis in a murine model Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: NI, Heyu 		Intramural Research Grant Program 400000.0
Modulation of biofilm formation, virulence, and antimicrobial resistance by Staphylococcus aureus during platelet storage Principal Investigator: RAMIREZ-ARCOS, Sandra

Co-Investigator(s) / Trainee: SAD, Subash, MAH, Thien-Fah 		Intramural Research Grant Program 323252.6
Improving blood product quality Principal Investigator: DEVINE, Dana

Co-Investigator(s) / Trainee: MA, Hongshen, JOHNSON, James, D'ALESSANDRO, Angelo 		Intramural Research Grant Program 304462.0
Monovalent Fc receptor blockade using novel fusion proteins: The road towards an IVIg replacement Principal Investigator: LAZARUS, Alan

Co-Investigator(s) / Trainee: SHEFFIELD, William, BRANCH, Donald 		Intramural Research Grant Program 400000.0
New cryosolution for stem cell-based therapeutics Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: BEN, Robert, HARPER, Marie-Ellen, CHAKRABORTY, Nilay 		Intramural Research Grant Program 180000.0
Controlling coagulopathy and bleeding in a mouse model of hemorrhagic shock Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: NAZY, Ishac 		Intramural Research Grant Program 274854.0
Influence of eryptosis and storage on transfused red cell recovery in sepsis Principal Investigator: SHEFFIELD, William

Co-Investigator(s) / Trainee: BRANCH, Donald, LIAW, Patricia, HEDDLE, Nancy, QADRI, Syed 		Intramural Research Grant Program 283569.0
Enabling next generation hematopoietic-based therapeutics and manufacturing Principal Investigator: PINEAULT, Nicolas

Co-Investigator(s) / Trainee: MCCOMB, Scott, JEZIERSKI, Anna, MAGALHAES, Ana, IQBAL, Umer 		Intramural Research Grant Program 300000.0
Biomarkers in patients with anemia-induced thrombocytopenic bleeding (BAIT): A pilot study Principal Investigator: ARNOLD, Donald

Co-Investigator(s) / Trainee: WEBERT, Kathryn, LIAW, Patricia, BERG, Tobias, HEDDLE, Nancy 		Intramural Research Grant Program 200000.0