Hypothermic Storage as an Alternative to Irradiation of Red Cell Concentrates
To prevent transfusion-related deaths that are a direct result of activation of the recipient’s immune system, Canadian Blood Services eliminates white blood cells (WBCs) from red blood cell (RBC) products using two industry-standard approaches: filtration followed by irradiation if clinically indicated. However, in addition to logistical challenges, irradiation has been shown to affect RBC quality thereby these irradiated products also possess a shorter shelf-life. Previous work by our group has demonstrated that extended hypothermic storage may be nearly as effective as irradiation in reducing the number and viability of any WBCs that remain post-filtration.
The objective of this study is to compare stored RCCs to units irradiated either a day or a week prior to transfusion in the context of 1) the number and functionality of their residual WBCs and 2) the quality of their RBCs. This will allow us to further characterize WBCs and RBCs in irradiated and hypothermic stored products. These results will inform blood product management by potentially eliminating the need for irradiation, particularly when access is limited.
The objective of this study is to compare stored RCCs to units irradiated either a day or a week prior to transfusion in the context of 1) the number and functionality of their residual WBCs and 2) the quality of their RBCs. This will allow us to further characterize WBCs and RBCs in irradiated and hypothermic stored products. These results will inform blood product management by potentially eliminating the need for irradiation, particularly when access is limited.
Principal Investigator / Supervisor
ACKER, Jason
Co-Investigator(s) / Trainee
CLARKE, Gwen
NAHIRNIAK, Susan
BRANDON-COATHAM, Mackenzie
OLAFSON, Carly
Institution
Canadian Blood Services
Program
Blood Efficiency Accelerator Program
Province
Alberta
Total Amount Awarded
30000.0
Project Start Date
Project End Date