Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
Transient warming affects potency of cryopreserved cord blood units Pasha R, Howell A, Turner TR, Halpenny M, Elmoazzen H, Acker JP, Pineault N 2020 Cytotherapy View Researchers New or improved product or process
Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs Wang A, Ribeiro RVP, Ali A, Brambate E, Abdelnour-Berchtold E, Michaelsen V, Zhang Y, Rahfeld P, Moon H, Gokhale H, Gazzalle A, Pal P, Liu M, Waddell TK, Cserti-Gazdewich C, Tinckam K, Kizhakkedathu JN, West L, Keshavjee S, Withers SG, Cypel M 2022 Sci Transl Med View Researchers Clinical research
Meta-Analysis of Risk of Vaccine-Induced Immune Thrombotic Thrombocytopenia Following ChAdOx1-S Recombinant Vaccine Chan BT, Bobos P, Odutayo A, Pai M 2021 medRxiv View Researchers Clinical research
The Effect of Sex-Mismatched Red Blood Cell Transfusion on Endothelial Cell Activation in Critically Ill Patients Alshalani A, van Manen L, Boshuizen M, van Bruggen R, Acker JP, Juffermans NP 2021 Transfus Med Hemotherapy View Researchers Clinical research
Mixing study to diagnose heparin-resistance caused by functional antithrombin deficiency Bahabri A, Moffat KA, Carlino SA, Chan AKC, Bhatt MD 2022 Int J Lab Hematol View Researchers Basic research
Filamin A regulates caspase-3 cleavage in platelets in a protein kinase C (PKC)-dependent manner De Silva E, Devine DV, Jan E, Roskelley CD, Kim H 2022 Biochem J View Researchers Basic research
Model of Acute Liver Failure in an Isolated Perfused Porcine Liver—Challenges and Lessons Learned Hefler J, Hatami S, Thiesen A, Olafson C, Durand K, Acker J, Karvellas CJ, Bigam DL, Freed DH, Shapiro AMJ 2022 Biomedicines View Researchers New or improved product or process
An evaluation of the clinical impacts of 7-day platelets Ning S, Gabarin N, Li N, Liu Y, Lucier K, Barty R, Acker J, Webert KE, Warkentin TE, Arnold DM, Heddle NM 2023 Transfusion View Researchers Clinical research
Coagulation and complement: Key innate defense participants in a seamless web Pryzdial ELG, Leatherdale A, Conway EM 2022 Front Immunol View Researchers Basic research
ResearchUnit: Evaluating infusion pump safety for red blood cell transfusions Wolfe A 2022 Blood.ca website View Researchers Benchmarking and standard setting
An analysis of the bias in red blood cell hemolysis measurement using several analytical approaches Acker JP, Croteau IM, Yi QL 2012 Clin Chim Acta View Researchers New or improved product or process
CD4+ T-cells are unable to express the HIV natural resistance factor globotriosylceramide Kim M, Binnington B, Sakac D, Lingwood CA, Branch DR 2013 AIDS View Researchers Basic research
Developing highly active small molecule ice recrystallization inhibitors based upon C-linked antifreeze glycoprotein analogues Trant JF, Briggs RA, Capicciotti C, Ben RN 2013 RSC Adv View Researchers Basic research
Donor iron policy: from research to practice O'Brien SF 2016 Transfusion View Researchers New or improved product or process
Enhanced Cell Surface Polymer Grafting in Concentrated and Nonreactive Aqueous Polymer Solutions Rossi NAA, Constantinescu I, Brooks DE, Scott MD, Kizhakkedathu JN 2010 J Am Chem Soc View Researchers Basic research
Fluids in sepsis and septic shock (FISSH): protocol for a pilot randomised controlled trial Rochwerg B, Millen T, Austin P, Zeller M, D'Aragon F, Jaeschke R, Masse MH, Mehta S, Lamontagne F, Meade M, Guyatt G, Cook DJ 2017 BMJ Open View Researchers Clinical research
Hepatoprotective effects of Poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] on alcohol-damaged primary rat hepatocyte culture in vitro Jiang W, Bian Y, Wang Z, Chang TMS 2016 Artif Cells Nanomed Biotechnol View Researchers New or improved product or process
Immunogenicity, efficacy and safety of Nuwiq® (human-cl rhFVIII) in previously untreated patients with severe haemophilia A-Interim results from the NuProtect Study Liesner RJ, Abashidze M, Aleinikova O, Altisent C, Belletrutti MJ, Borel-Derlon A, Carcao M, Chambost H, Chan AKC, Dubey L, Ducore J, Fouzia NA, Gattens M, Gruel Y, Guillet B, Kavardakova N, El Khorassani M, Klukowska A, Lambert T, Lohade S, Sigaud M, Turea V, Wu JKM, Vdovin V, Pavlova A, Jansen M, Belyanskaya L, Walter O, Knaub S, Neufeld EJ 2017 Haemophilia View Researchers Clinical research
Influence of polymer architecture on antigens camouflage, CD47 protection and complement mediated lysis of surface grafted red blood cells Chapanian R, Constantinescu I, Rossi NA, Medvedev N, Brooks DE, Scott MD, Kizhakkedathu JN 2012 Biomaterials View Researchers Basic research
MDM2 antagonist nutlin plus proteasome inhibitor velcade combination displays a synergistic anti-myeloma activity Saha MN, Jiang H, Jayakar J, Reece D, Branch DR, Chang H 2010 Cancer Biol Ther View Researchers Basic research
Nouvelle cuisine: platelets served with inflammation Kapur R, Zufferey A, Boilard E, Semple JW 2015 J Immunol View Researchers Basic research
Subunit-directed click coupling via doubly cross-linked hemoglobin efficiently produces readily purified functional bis-tetrameric oxygen carriers Singh S, Dubinsky-Davidchik IS, Yang Y, Kluger R 2015 Org Biomol Chem View Researchers Basic research
The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody–mediated amelioration of murine immune thrombocytopenia Crow AR, Suppa SJ, Chen X, Mott PJ, Lazarus AH 2011 Blood View Researchers Basic research
Thrombocytopenia in the critically ill Shehata N, Fontes ML 2013 Can J Anaesth View Researchers Other
Transfusion-transmitted malaria: is hope around the corner? O'Brien SF 2016 Lancet View Researchers Other
Vitamin D and kidney transplant outcomes: a protocol for a systematic review and meta-analysis Hesketh CC, Knoll GA, Molnar AO, Tsampalieros A, Zimmerman DL 2014 Syst Rev View Researchers Clinical research
ResearchUnit: Patient blood group impacts susceptibility to IVIg-associated hemolysis Branch D 2018 Blood.ca website View Researchers Basic research
A Deep Learning Method to Automatically Identify Reports of Scientifically Rigorous Clinical Research from the Biomedical Literature: Comparative Analytic Study Del Fiol G MM, Iorio A, Cotoi C, Haynes RB 2018 J Med Internet Res View Researchers Clinical research
The peptidoglycan and biofilm matrix of Staphylococcus epidermidis undergo structural changes when exposed to human platelets Loza-Correa M, Ayala JA, Perelman I, Hubbard K, Kalab M, Yi Q-L, Taha M, de Pedro MA, Ramirez-Arcos S 2019 PLoS One View Researchers Basic research
Systematic reviews of guidelines and studies for single versus multiple unit transfusion strategies Shih AW, Liu A, Elsharawi R, Crowther MA, Cook RJ, Heddle NM 2018 Transfusion View Researchers Clinical research
Evaluating the quality of red blood cell concentrates irradiated before or after cryopreservation Turner TR, Lautner L, Hill A, Howell A, Skeate R, Acker JP 2020 Transfusion View Researchers Basic research
Antithrombotics from Frog Skin Secretions Ni H 2020 Thromb Haemost View Researchers Basic research
FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity Hubbard JJ, Pyzik M, Rath T, Kozicky LK, Sand KMK, Gandhi AK, Grevys A, Foss S, Menzies SC, Glickman JN, Fiebiger E, Roopenian DC, Sandlie I, Andersen JT, Sly LM, Baker K, Blumberg RS 2020 J Exp Med View Researchers Basic research
Potentially clinically significant anti-Dib identified by monocyte monolayer assay before transfusion Branch DR, Holton MB, Ison T, Cote J, Dube C, Lau W 2021 Transfusion View Researchers Basic research
Serotonin-release assay-positive but platelet factor 4-dependent enzyme-immunoassay negative: HIT or not HIT? Warkentin TE, Smythe MA, Ali MA, Aslam N, Sheppard JI, Smith JW, Moore JC, Arnold DM, Nazy I 2021 Am J Hematol View Researchers Clinical research
The utility of a monocyte monolayer assay in the assessment of intravenous immunoglobulin–associated hemolysis Tong TN, Blacquiere M, Sakac D, Burke-Murphy E, Yi Q, Callum J, Cserti-Gazdewich C, Parmar N, Shehata N, Pavenski K, Lau W, Lin Y, Lieberman L, Branch DR, Pendergrast J 2020 Transfusion View Researchers New or improved product or process
Non-invasive monitoring of red blood cells during cold storage using handheld Raman spectroscopy Vardaki MZ, Schulze HG, Serrano K, Blades MW, Devine DV, Turner RFB 2021 Transfusion View Researchers New or improved product or process
Retention of hemostatic and immunological properties of frozen plasma and COVID-19 convalescent apheresis fresh-frozen plasma produced and freeze-dried in Canada Sheffield WP, Bhakta V, Howell A, Jenkins C, Serrano K, Johnson N, Lin Y-CJ, Colwill K, Rathod B, Greenberg B, Gingras A-C, Evans DH, Flaumenhaft E, Beckett A, Drews SJ, Devine DV 2022 Transfusion View Researchers Basic research
Comparison of Neutrophil Function in Granulocyte Concentrates From Prednisone- and G-CSF-Treated Donors: Effect of Stimulant, Leukapheresis and Storage Murru A, Allard M-È, Paré G, Vaillancourt M, Boyer L, Cayer M-P, Vitry J, Landry P, Labrecque M-M, Robitaille N, Branch DR, Girard M, Fernandes MJ 2022 Front Med View Researchers Basic research
Lessons from vaccine-induced immune thrombotic thrombocytopenia Kelton JG, Arnold DM, Nazy I 2021 Nat Rev Immunol View Researchers Clinical research
Comparative 6-Month Wild-Type and Delta-Variant Antibody Levels and Surrogate Neutralization for Adults Vaccinated with BNT162b2 versus mRNA-1273 Grunau B, Golding L, Prusinkiewicz MA, Asamoah-Boaheng M, Armour R, Marquez AC, Jassem AN, Barakauskas V, O’Brien SF, Drews SJ, Haig S, Lavoie PM, Goldfarb DM 2022 Microbiol Spectr View Researchers Clinical research
Preservation and Storage of Cells for Therapy: Current Applications and Protocols Acker JP, Bondarovych M, Brunotte R, Buriak IA, Fuller BJ, Glasmacher B, Goltsev AM, Gregor J, Gryshkov O, Herrity K, Honegrová B, Hunt CJ, Jandová M, Johnstone BH, Kilbride P, Lánská M, Mann J, Měřička P, Musall KG, Mutsenko V, Mykhailova O, Petrenko Y, Radocha J, Sherry AM, Stacey GN, Štěrba L, Vokurková D, William N, Woods EJ 2022 Cell Engineering and Regeneration View Researchers Benchmarking and standard setting
Cross-Canada Variability in Blood Donor SARS-CoV-2 Seroprevalence by Social Determinants of Health O’Brien SF, Caffrey N, Yi Q-L, Bolotin S, Janjua NZ, Binka M, Thanh CQ, Stein DR, Lang A, Colquhoun A, Pambrun C, Reedman CN, Drews SJ 2023 Microbiol Spectr View Researchers Clinical research
The response of a human haematopoietic cell line to trehalose-loaded liposomes and their effect on post-thaw membrane integrity Scott KL, William N, Acker JP 2022 Cryobiology View Researchers Basic research
Evaluating variation in perioperative red blood cell transfusion for patients undergoing elective gastrointestinal cancer surgery Zuckerman J, Coburn N, Callum J, Mahar AL, Lin Y, Turgeon AF, McLeod R, Pearsall E, Martel G, Hallet J 2023 Surgery View Researchers Clinical research
[Study on the relationship of platelet specific-autoantibodies with therapeutic outcomes by dexamethasone in immune thrombocytopenia purpura] Chen Y, Ge J, Ruan M, Zhu L, Xie Y, Xia R, Ni H, Zeng Q 2015 Zhonghua Xue Ye Xue Za Zhi View Researchers Clinical research
Advances in umbilical cord blood stem cell expansion and clinical translation Pineault N, Abu-Khader A 2015 Exp Hematol View Researchers Other
Angiogenesis and bleeding disorders in FNAIT Yougbare I, Zdravic D, Ni H 2015 Oncotarget View Researchers Clinical research
Blood bag plasticizers influence red blood cell vesiculation rate without altering the lipid composition of the vesicles Bicalho B, Serrano K, dos Santos Pereira A, Devine D, Acker J 2016 Transfus Med Hemother View Researchers Basic research
Comparison of bacterial attachment to platelet bags with and without preconditioning with plasma Loza-Correa M, Kalab M, Yi QL, Eltringham?Smith L, Sheffield W, Ramirez-Arcos S 2017 Vox Sang View Researchers Basic research